What does marijuana do? It rebalances everything

[see also: “Can we please stop assuming that marijuana is harmful to young people?“]

The “simplest” accurate description of the effects of marijuana in humans is that it modulates the regulation of homeostasis. Homeostasis is what Goldilocks seeks in the children’s story: not too hot; not too cold; just right. More than just heat and cold, the human body contains many systems which must be held in relative balance. The balance between inhibition and excitation, bone formation and resorption, inflammatory/anti-inflammatory signalling, fat storage and release, blood sugar, blood pressure, hormone levels; all these systems are held in balance by the endocannabinoid system. This system, though involved in maintaining nearly every biological process in all humans, has only received scientific study for roughly the past 20 years, and it was discovered because it’s the site of action for marijuana.

Marijuana does not simply activate (agonise) this system. In addition to full cannabinoid agonists (chemicals which stimulate — agonise; antonym: antagonise — receptors), it also contains partial agonists, antagonists (Thomas, 2007), reuptake and transport inhibitors, enzyme modulators and much else besides, (Russo, 2011) including an assortment of terpenoids  and flavinoids responsible for the odour of the flowers; how a marijuana strain smells indicates what mix of chemicals (all of which appear to be pharmacologically active in humans) are present, beyond the most famous two, neither of which have an odour: THC and CBD. The most studied receptors in the endocannabinoid system are called CB1 and CB2, both of which inhibit the other (Callén et al 2012), and both of which are stimulated by THC (a partial agonist at both and other sites) and antagonised by CBD (Thomas et al, 2007). There are also believed to be numerous other receptors involved (Petrocellis, 2009), and their scientific study is yet only preliminary and largely speculative. Far from a single chemical with a single mode of action, marijuana has an entourage effect: many chemicals working together to produce effects not reducible to the action of only one or two of its constituents. One chemical it often contains in relatively large quantities, for example, is caryophyllene, a selective full CB2 agonist which is also found in cloves, rosemary, hops and eucalyptus. Other plants which work on cannabinoid receptors include hot pepper and vanilla. Through their presence in the diet of some marijuana users, these (and other) plants participate in the entourage effects of marijuana in modulating the regulation of homeostasis.

Summary: it rebalances almost every system in the body through multiple inter-related effects which move in several directions at once and which compensate for each other’s effects (confused yet?)


But what does it all DO?

Research into the effects of marijuana has been aided by intense and widespread public interest, but hindered in recent decades by efforts by various parties to suppress any investigation into possible benefits and to spread claims of possible harms (no matter how tenuous), as part of the “war on drugs.” As an ethnographer working with young drug users in person and on the internet, as well as having read widely on the subject, these are the effects I have most often found credibly attributed to marijuana:

Increased appetite, change in the perception of time, relief from pain, intensified awareness (both inside and outside the body), relaxation, euphoria, increased heart rate, lower blood pressure, emotional release, increased vigor, lethargy, inhibited memory, increased creativity, intense introspection, reveries, flights of fancy, lower body temperature, increased sexual pleasure, reduced sexual desire, relief from nausea, greater aesthetic appreciation, magical thinking, heightened interest in spiritual phenomena, and both increased and decreased anxiety (presumably different types of anxiety).

Reported medically relevant effects of marijuana also include bronchodilation, decreased intracranial and intraocular pressure, glucagon release, reduction in insulin tolerance, lymphocyte suppression, antimicrobial, anticonvulsant, antipsychotic, psychotomimetic, anti-inflammatory, antiemetic, antinociceptive and anticarcinogenic effects.

Occasionally marijuana causes many strange and idiosyncratic effects not here described. Some of these may sometimes be labelled as psychotic or spiritual, but these effects are typically short-lived; they do not last and often cannot be produced reliably or consistently, making them difficult, if fascinating, to study.

Many of marijuana’s effects appear to be highly context- and dose-dependent. In small and occasional doses, it is often more stimulating, boosting appetite and providing relief from depression, whereas in very large and frequently repeated doses, these effects may reverse, with less appetite and relative inactivity. While it influences every organ system, its direct effects are largely confined to the maintenance of homeostasis, which it pushes not just in one direction but in several, counteracting and balancing out its own effects. Even a massive overdose will generally have a negligible impact on long term health, though it may be disorienting until it wears off.

The stimulating effects of THC typically last 2-3 hours, whereas the half-life of CBD, which is more relaxing, is 9 hours. Thus, the first dose of marijuana after a period of abstinence will tend to be far more stimulating than subsequent doses, which must compete with the relaxing effects of previous doses, because the relaxation both persists much longer and shares many of the same pathways as the stimulation. Regular ingestion of THC also leads to increased tolerance to its stimulating effects, but not to its relaxing effects, with very heavy use associated with a reversible 20% reduction in CB1 receptor density in some areas of the brain (Hirvonen et al, 2012); THC itself provides a longer term mild relaxing effect than the immediate boost. As cannabinoid activity can produce anxiety, it may well be that developing tolerance to the drug may itself protect against anxiety on a longer time scale; in a sense, by getting high you can get your anxiety out of the way while also benefiting from a variety of relaxing and euphoric effects to counteract it, rather than having to deal with constant, unremitting anxiety. Notably, Hirvonen et al only found the reduction in receptor density in only some areas, so this long term down-tuning does not affect all of the processes influenced by THC, but only some of them. In any case, we need to consider not just the immediate high, but also its persisting effects, if we are to understand the consequences of its use in humans.

Summary: it does lots of things, and sometimes also the opposite. (maybe this will be easier if we go system by system…)

Homeostasis 2


Marijuana in the Brain

The brain’s major inhibitory neurotransmitter is GABA, and the major excitatory neurotransmitter is glutamate; the endocannabinoid system regulates the levels of each of these by selectively suppressing them as called for, hopefully maintaining an appropriate balance. THC temporarily boosts this process, suppressing both inhibition and excitation. With GABA suppressed, a wide variety of effects and processes which would otherwise have been inhibited become more free to play themselves out. This explains the sensory enhancements commonly experienced by marijuana users, with increased sensitivity to smell, sight, sound, texture and much besides, including sexual pleasure. This is probably also the best scientific explanation for its occasionally outlandish effects, from the merely weird to the deeply spiritual to the profoundly unsettling: the mind, unleashed and uncontained, for better or for worse. Glutamate, though itself excitatory, excites neural networks which inhibit various behaviours, and so its suppression may contribute not only to relaxation but also to some of marijuana’s behavioural effects, such as indulgence in magical thinking and the wild dancing. Importantly, glutamate can also damage brain cells (excitotoxicity), and so suppressing it provides some protection brain damage as it occurs in head injury, epilepsy, hypoglycaemia, stroke, alcohol or benzodiazapine withdrawal and a variety of neurodegenerative conditions including multiple sclerosis, Parkinson’s Disease, Alzheimer’s Disease and Huntington’s Disease, among other conditions. Cannabinoid receptors on glial cells are involved in memory storage, recall, and forgetting (Lane et al, 2005), as well as the extinction of conditioned place preferences more specifically (Parker et al, 2004), suggesting that marijuana use may make it easier to adapt to new contexts and to forget old habits. It fundamentally changes how we experience the passage of time; in Hindu mythology, Lord Shiva, poisoned by time, takes marijuana which relieves his anxiety so that he begins to dance, and through his dance the poison is neutralised, thus saving the universe from being destroyed by an imbalance between space and time. Many experiments have shown that marijuana use impairs performance at certain memory tasks, but that this effect disappears after a period of abstinence, and so cannot be described as damage. Rather than merely the absence of remembering, forgetting is an active process by which we let go of extraneous or harmful memories (White, 2001; Pollan, 2002); by boosting forgetting functions through its effects on glial cells, marijuana may provide relief from traumatic memories. (Marcisano, 2001) The creative benefit most commonly cited by artists who use marijuana is in improvisation, getting into the flow so that strange new rhythms can emerge, fascinate and delight. (Fachner, 2003) More research is necessary, but I suspect that increased forgetting and increased improvisation are linked, and that a good description of marijuana’s creative effects might be less rote repetition and more novel recombination; whether that will be desirable or harmful will depend on the task at hand.

Marijuana is very popular among people with ADHD, for whom it may be synergistic with their tendency to hyperfocus, sometimes used to push past ennui into full dynamic engagement (the term for which in the cognitive sciences is “flow”), though it also tends to increase restlessness and can make them even more distractable, especially in larger doses, and so ADHD people often find very small doses to be the most helpful. (Loflin, 2014) One physiological description of ADHD is impaired dopamine transporter function, and the most common pharmaceutical interventions for ADHD are psychostimulants such as amphetamines which stimulate dopamine release directly. Marijuana, on the other hand, does not increase dopamine signalling, but modulates salience through other pathways. For this reason, many ADHD people find that marijuana feels more “natural,” ebbing and flowing with the context, whereas amphetamines often feel forced or artificial. Another difference is that amphetamines often make it very difficult to eat and sleep, whereas marijuana boosts appetite and, for many of its users, provides unusually restful and easy sleep. This is extremely important, because poor sleep and poor diet are major sources of harm among people with ADHD.

Some autistic people have also found marijuana to be of benefit in relieving the overstimulation-related emotional anxiety and tension which can inhibit their behaviour. Recent evidence has emerged that autism may in part be caused by abnormalities in cannabinoid signalling (Földy, 2013), so it seems that the rebalancing effect of marijuana directly interacts with some of the underlying causes of autism. One physiological description of autism is too much glutamate and not enough GABA; by suppressing both glutamate and GABA, marijuana may essentially level the playing field, so that a stoned neurotypical and a stoned autistic person end up on roughly the same level.

In neither ADHD nor autism does marijuana merely suppress symptoms and make a person “normal”; far from it. What it does is to rebalance many metabolic, attentional and neural systems, reconfiguring any problematic balance which may be in place, and producing a new state of consciousness unlike either neurotypical consciousness or the typical expression of either ADHD or autism. That is, it may normalise homeostasis, but to do so is not necessarily normative, in the anthropological sense.

In summary, marijuana rebalances excitation and inhibition in ways which are sometimes highly valued, and which may correct for or prevent imbalances in attentional and cognitive systems.

Marijuana benefits and risks

Marijuana, Neuroprotection and Brain Damage

In addition to preventing glutamate excitotoxicity and neuroinflammation, marijuana also reduces the volume of fluid in the head following head injury, lowers brain temperature (trivia: the popular fever reducer sold as Tylenol works partially by breaking down into  a cannabinoid reuptake inhibitor, and therefore shares a pathway with marijuana (Bertolini, 2006)) and prevents prion accumulation (Dirikoc et al, 2007), all of which are ways by which it’s known marijuana can protect against brain damage. It also reduces risk of such neurodegenerative conditions as Parkinson’s Disease and Alzheimer’s Disease through other mechanisms besides. (Ramirez et al, 2005Eubanks et al, 2006) However, because of the pressure from the US government to publish (or fabricate) harms from marijuana, several widely publicised studies have been used to claim that marijuana causes brain damage. In every case, these studies either suggested nothing of the kind when properly interpreted, or were confounded enough to be worthless, and there is, at time of writing, absolutely no credible evidence of any form of brain damage from marijuana use in humans. In a classic example, one team of researchers forced rhesus monkeys to inhale large volumes of smoke, depriving them of oxygen in the process, and attributed their mental decline to marijuana rather than to oxygen deprivation. (Heath et al, 1980) Not surprisingly, subsequent studies failed to reproduce their finding. (Slikker et al, 1990; Paule et al 1992) Other studies have shown mental deficits and brain abnormalities in some young heavy marijuana smokers (Meier, 2012; Smith, 2013, Gilman et al 2014), but it’s highly likely that both the observed deficits and the marijuana use were caused by the same factor, rather than the deficits being caused by the marijuana use, as the deficits are only found in a minority of teenagers who use marijuana, and because there are a variety of sources of deficit which also predict marijuana use. (Tims, 2002) Post traumatic stress disorder (PTSD; often a product of child abuse) is a likely candidate, because it predicts both cognitive deficits (Moradi et al, 2013) as well as adolescent drug use (Maté, 2008Dube, 2003), including heavy cannabis use. (Cornelius et al, 2009) For people with PTSD, marijuana may correct a chronically dysfunctional stress response (Heim et al, 2000) and make it easier to forget painful memories (Ganon-Elazer 2012; Patel et al, 2004Marcisano et al, 2001). Regrettably, in none of the studies in which deficits were shown to be correlated with heavy early-onset marijuana use did researchers attempt to control for the enormous confound of past trauma. In light of the indications that marijuana is useful in the treatment of PTSD, to attribute the harms of trauma to a plant being used to alleviate it is particularly bothersome. There has also been a disturbing tendency in news coverage report all findings of alteration as “damage,” even where no deficits, and indeed some potential benefits, were shown. Given the ongoing drug war and propaganda efforts by various governments, the utmost skepticism is warranted in interpreting claims of marijuana-induced brain damage, none of which (to date) survive careful scrutiny grounded in the appropriate scientific literature. Given what we’ve learned about marijuana’s effects the dire claims seem ever more preposterous, especially given the many marijuana users who have distinguished themselves in scientific and artistic communities alike.

Rather than simply accusing hemp flowers of harming teenagers, a more sensible approach might be to listen to teenagers who are heavy marijuana users, to understand why they’re using it and what they’re getting out of it, bearing in mind that they may well be survivors of abuse, which agents of the legal, medical and educational systems may have directly participated in rather than alleviating. Stigma, theft of medicine, segregation and punishment are unacceptable responses to observed suffering.

In summary: marijuana rebalances and soothes a variety of neural processes and can protect against numerous potential sources of damage. No form of brain damage has been demonstrated to have resulted from its use.

Sagan High

Marijuana and Metabolism

The endocrine system consists of glands throughout the body which regulate everything from energy levels to metabolism to sex drive. CB1 receptors can be found throughout this system and influence the release of many hormones. One function of this system is to produce excitation in response to stress. This is necessary for survival, but when it gets out of hand it can be a major source of harm, especially in a fast paced modern economy where stress may be relentless. One effect of marijuana in the endocrine system seems to be to protect against this, by reducing susceptibility to stress-induced activation in the hypothalamus-pituitary-adrenal axis. (Patel et al, 2004) The details of how it does this, as well as all of its other diverse and complex effects throughout the endocrine system, however, remain murky, but are becoming clearer and will likely continue to do so over the coming years.

Marijuana’s ability to boost appetite is well known, and it is used to treat anorexia as well as diet problems resulting from other drug therapies, such as in patients with AIDS or cancer. Part of this effect on appetite may be because GABA suppression increases the rewarding stimulation from food; another part is its ability to block nausea, including the nausea induced by chemotherapy drugs. While there is a stereotype of getting high and then gorging on lots of delicious food, many of my respondents have informed me that they actually prefer to get high after their meal, finding it to improve their digestion and settle their stomach. It’s also common for “the munchies” to not set in until around 45 minutes after dosing, and it’s here that the endocrine effects, specifically in the pancreas, are explanatory. The pancreas secretes the pair of hormones glucagon and insulin to regulate blood sugar by signalling the liver to break down fat into sugar (glucagon) or to store sugar as fat (insulin). These hormones work as a pair to maintain homeostasis, and they stimulate the release of each other through a complex feedback mechanism. In 2008, it was determined that CB1 activation triggers glucagon release and that CB2 activation lowers glucose-dependent insulin release. (Bermudez-Silva et al, 2008) This helps to explain why marijuana users tend to eat more calories but do not gain any extra weight, have less obesity and lower rates of type II diabetes than non-users (Rodondi et al, 2006Le Strat, 2011Rajavashisth et al, 2012), and why some diabetics find that marijuana makes it easier to manage their blood sugar, as marijuana rebalances the relative levels of glucagon and insulin, although anti-inflammatory effects are also relevant.  Type II diabetics (whose pancreas still functions) tend to have very high levels of insulin, but the liver is unable to use it, and so blood sugar stays high, and the pancreas damages itself by trying to continually produce more and more insulin, eventually leading to organ failure if the diabetes is unmanaged. By boosting glucagon release and lowering insulin resistance, marijuana may alleviate or prevent the progression of type II diabetes and restore balance to the system.  The endocannabinoid system is also separately involved in fat storage (Cota, 2003Osei-Hyiaman et al, 2005) (interestingly, THC is also fat soluble, and so it seems to be storing itself through this process, and is released back into the bloodstream during exercise (Wong et al, 2013)), and some studies have found marijuana users to have more fat in visceral tissue. (Hézode et al, 2008Muniyappa, 2013) Cannabinoid antagonists have also been shown to reduce obesity, and not only do rodents given these drugs eat less, they also lose more weight than their reduced feeding can account for. (Pagotto et al, 2006) What exactly this means for users of marijuana (which contains both cannabinoid agonists and antagonists) remains unclear (more fat storage through one mechanism, and less fat storage through another), but the findings of lower rates of obesity and diabetes among marijuana users — despite correlations between marijuana use and a variety of life-style risk factors, including heavier eating — are very promising. Marijuana use is certainly not a major source of harm in this system, and may be of benefit in a variety of (very common) circumstances.

Cannabinoid signalling is also involved in many reproductive functions in both males and females, including in foetal development, and there are even CB receptors on sperm themselves. While the effects of marijuana on sperm and reproductive functions are not well understood, it appears that regular marijuana use may moderately reduce both menses and sperm production, and that therefore while many marijuana users can still conceive, it may be prudent for couples having difficulty conceiving to refrain from using marijuana. On the other hand, many find marijuana to improve their experience of sex, and it even allows for orgasm in some otherwise anorgasmic women. Not enough is known about its effects on pregnancy to be confident as to when it may be of benefit or harm to the foetus, (Pagotto et al, 2006) but it is commonly used to alleviate the nausea associated with morning sickness.

A stereotype of marijuana users is that they are lazy and that the drug makes them inactive. Traditional Hindu practices assume that this is the case, and discourage its use by home-owners, while allowing it to ascetics in the process of renouncing worldly attachments. (Morningstar, 1985) Some marijuana users certainly seem drawn to renunciation, and may show little interest in material advancement, especially when using heavily. Many others, however report that its effects are stimulating, and there have been many elite athletes who used marijuana, including martial arts legend Bruce Lee, basketball legend Kareem Abdul-Jabbar, Olympic gold medallists Michael Phelps and Ross Rebagliati, and more than half of the Oregon Ducks football team. Clearly, its effects are not disastrous to fitness or to the ability to exercise. Noted astronomer Carl Sagan and physicist Richard Feynman both used marijuana to stimulate visionary states and the flow of ideas; a great many other musicians, writers, scientists and artists have admitted to doing so as well. Many of the same have admitted at other times that marijuana can interfere with their performance or leave them distracted and tired. Its effects can be very inconsistent, and depend on the user’s metabolism, dosing strategy and the chemical composition of the strain being used.

In summary, marijuana rebalances energy levels, fat storage, reproductive functions, appetite and metabolism, and can correct for imbalances such as in type II diabetes, anorexia and a variety of stress-related disorders.


Marijuana and Mental Health

The use of marijuana is often seen in people who suffer from a wide variety of mental health problems (Wittchen et al 2007), for which it is often used to self-medicate, for better or for worse. It  is known to sometimes relieve depression (Denson, 2006), emotional anxiety (Fusar-Poli et al, 2010) and intense stress (Ganon-Elazer, 2012). However, through its powerful and pervasive effects, it  may well trigger an episode of any number of conditions, such as underlying psychoses. Some use marijuana precisely to provoke an inexplicable or extreme mental state, which may be interpreted as either spiritual or psychotic, or to produce greater and longer lasting states of elation and activity (mania), and many religious and shamanic groups have employed it to facilitate communication with spirits, to transport the user to heaven, to destroy karma, to deepen a trance, and much else besides. Marijuana surely is a drug favoured by lunatics and maniacs, not only to end their lunacy or mania but sometimes to provoke it. Does that make it dangerous to people who do not want these effects? Especially, perhaps if they despise the moon?

Much has been made of the association between cannabis use and schizophrenia. Schizophrenia (literally: broken mind) is a diagnostic category which consists of an unknown number of poorly understood mental types, characterised by positive symptoms such as delusions, hallucinations and disordered thinking, and negative symptoms such as not finding pleasure in anything and not being interested in talking to the other humans. Best estimates suggest that around 1 in 100 people will be exhibit schizophrenia at some point during their life, or 1.4 in 100 people who have ever used marijuana. (Zammit, 2007) This makes it a moderate risk factor, but less severe than being a first or second generation immigrant, having a father over the age of 55 at the time of birth, being raised in an urban area, or infection with Toxoplasma gondii, a parasite common among cat owners. (Bourque et al, 2011Torrey et al, 2012) All of the above effects are dwarfed by familial predisposition, and Proal et al recently found that schizophrenic marijuana users are just as likely to have schizophrenic relatives as schizophrenics who do not use marijuana, suggesting that marijuana is not a cause of schizophrenia at all, but it’s just that schizophrenics are more likely than non-schizophrenics to use marijuana. (Proal et al, 2014) If we wish to reduce risk factors for schizophrenia, we may be better served by banning cats. Other research has suggested that “cannabis induced psychosis,” most characterised by paranoia, is at least partially a direct result of legitimate paranoia occasioned by the war on drugs, rather than the plant itself. (Hamilton et al 2014) There is some evidence that marijuana users with psychosis display more positive symptoms (such as paranoia) and less negative symptoms (such as anhedonia) (Zammit, 2008); this is especially interesting because mainstream psychiatry lacks an effective treatment for the negative symptoms, and it may be that many people are self medicating with marijuana for precisely this reason. Not only do people with psychosis use more marijuana than people without psychosis, but Giuffrida et al found that the body may be responding to schizophrenia by increasing endocannabinoid expression, and that this was associated with a reduction in symptom severity. (Giuffrida et al, 2004) Should we be surprised that some schizophrenics are drawn to a plant which mimics some of the body’s defence mechanisms against their symptoms? Lastly, while THC may occasionally produce psychotomimetic effects (that is, very stoned people may appear to be psychotic until they sober up), CBD appears to be anti-psychotic, (Zuardi et al, 2006) and so modulating the endocannabinoid system, for example with a high-CBD strain of marijuana, may be clinically useful in managing the positive symptoms of psychosis as well as the negative ones. In short, the evidence does not support the claim that using marijuana puts you at greater risk for harms from psychosis; perhaps even the opposite is the case, but more research is necessary. Indeed, prohibition is, itself, undeniably a far greater source of harm, for example by severely exacerbating such problems as racial oppression. (Fellner, 2000) Whether the same would be true for the prohibition of cats remains to be tested.

Among people living under the description of bipolar disorder, marijuana is the number one drug of choice, and those who use marijuana have less depression and more mania than those who do not. (Leweke, 2008) This is not surprising, given marijuana’s potential to increase positive symptoms and decrease negative ones. As there are strong cultural forces which value the creativity and charisma of mania and demonise depression, and because people living under the description of bipolar disorder typically identify with their hypomanic self rather than with a sober baseline, (Martin, 2007) marijuana is often used to improve mood and productivity, as well as to deal with stress in highly demanding contexts, with occasionally destabilising or dangerous consequences. To understand its effects in bipolar disorder, therefore, it is necessary to compare its users to others facing similar contexual pressures — for example, are university students (or entrepreneurs) more or less likely to “burn out” if they use marijuana? It’s also important to remember that marijuana has anti-depressant effects and is used to produce stimulation among people who do not have bipolar disorder, as well as by those who do. It’s not surprising that people with bipolar tendencies use it for the same reasons that others use it, even knowing it may increase the likelihood or intensity of a manic episode. Such people would do well to monitor their use (or to recruit friends and family to help monitor their use), and to consider refraining from using if they have a history of making dangerous decisions while manic.

In summary, marijuana rebalances mood, anxiety and attention in ways which may correct for or prevent certain forms of imbalance, but which may also upset a tenuous balance.


Marijuana in the Heart and Lungs

Much attention has been paid to the effects on the lungs of smoking marijuana, because of the severe and well known harms from smoking tobacco. Marijuana smoke contains many of the same carcinogens as tobacco smoke, and some in far higher concentrations (Moir et al, 2008), and so it was expected that it would be a cause of lung disease, as those chemicals are believed to cause cancer and emphysema in tobacco smokers. This however turns out not to be the case; marijuana smokers do not have elevated rates of lung cancer or emphysema, the two main debilitating effects of chronic tobacco smoking, and none of its long term effects on lung function are of clear clinical significance. (Tashkin, 2013) The analogy therefore can be rejected: marijuana is not dangerous in the ways that tobacco is dangerous. In fact, tobacco smokers who also smoke marijuana have lower rates of cancer and emphysema than do tobacco smokers who do not smoke marijuana, (Aldington, 2007) suggestive of the medicinal and/or protective effects of the flower vapours. Some marijuana smokers experience significant irritation and pain in the lungs which worsens over years of smoking, which may lead to a severe cough, and which is consistent with chronic bronchitis, but this often disappears if they switch from smoking to vaporising, even after decades of heavy smoking (vaporising is a method in which the plant matter is heated enough to convert the active compounds into a gaseous form, but below a temperature which would burn the plant matter, thereby avoiding the toxic byproducts of combustion). The lack of association between marijuana smoking and cancer, despite the well documented ample presence of known carcinogens, is strong evidence of its anti-carcinogenic effects; the chemicals it contains seem to compensate for the harmful effects of smoke inhalation (this is far from the only evidence of anti-carcinogenic effects (Ligresti et al, 2006), but it is suggestive as to their extent and efficacy in the wild). Marijuana, as a bronchodilator and an anti-inflammatory, has also been used in the treatment of asthma, and many asthmatic marijuana users have reported that their symptoms reduced during their period of use. (Williams, 1976)

Another major cause of death in tobacco smokers is heart disease, and, like the lung effects, there’s no evidence of elevated levels of coronary disease in marijuana smokers, despite the presence of various toxins in marijuana smoke. In the heart, the effects of marijuana are quite clear: decreased blood pressure, increased heart rate, often by as much as 30% , with CB1 and CB2 receptors as elsewhere working in opposite directions to control blood vessel dilation and other aspects of cardiovascular function. For most users this is not an appreciable concern, although it’s not uncommon for marijuana users to abort exercise because of strange feelings in their heart, or specifically because they feel that their heart is pumping too quickly or strongly. Some people with chronically low blood pressure find that they react badly to marijuana, and it is common for people under the acute influence of alcohol — which also lowers blood pressure — to become dizzy or nauseous if they proceed to smoke marijuana. Doing so may result in “the spins,” a very uncomfortable feeling where the world appears to be spinning and only spins faster if one closes one’s eyes. It is highly advisable therefore not to smoke marijuana while already drinking, especially if one is not a regular marijuana user and may be taken by surprise by the blood pressure crash. Smoking and then drinking does not appear to be nearly so dangerous, partly due to relative ease of dose control (you can sip your drink, but you cannot unsmoke a joint).

In people at elevated risk, a heart rate boost of 30% can trigger a heart attack. It has been estimated that marijuana smoking may increase risk for the next hour of myocardial infarction (heart attack) by a similar extent to having sex or exercising. Therefore, if your doctor has told you to abstain from sex due to the danger to your heart, you should consider also abstaining from marijuana. However, just because it’s more likely for a heart attack to take place during that window doesn’t mean it increases the risk of a heart attack happening at all. Indeed, a study of 3886 people who had already had at least one heart attack found no statistically significant association between marijuana use and death over an 18 year period (Frost et al, 2012), so there’s no great cause for worry. Instead, it seems to be the case that, if someone was going to have a heart attack anyway, it’s liable to happen within an hour of getting high, because of marijuana’s circulatory effects. CB1 activation has also been shown to worsen the damage from repurfusion (the shock caused by oxygen returning to cells temporarily deprived of it due to a heart attack), whereas CB2 protects against this damage, as well as against plaque instability and inflammation, such as in atherosclerosis (remember, THC activates both CB1 and CB2, so it both helps and hinders at the same time). CBD, meanwhile, has other non-cannabinoid receptor mediated cardioprotective effects. A high-CBD strain of marijuana may therefore be more beneficial for people at risk for heart attack than a high-THC strain. (Russo, 2006) For those concerned about heart and lung effects, vapourising or eating marijuana may be preferable to smoking it, as that will greatly reduce exposure to a variety of toxins. That said, the appropriate level of concern for smoking marijuana is probably more comparable to the dangers of toasting bread instead of eating it raw than it is to smoking tobacco, and many users will continue to consider this an acceptable trade-off for the convenience and ease of dose-control which come from smoking. (Montecucco, 2012)

In summary, marijuana rebalances dilation and contractility in the heart and lungs and may correct for or prevent such imbalances as usually result from smoke inhalation.


Marijuana in the Bones, Muscles and Joints

Unlike the many hard objects we encounter outside the body, our bones are constantly being broken down and remade. In young people there is typically more growth than break-down; this levels off and then reverses with age, and, as bone formation is driven by estrogen, post-menopausal women, women who have had their ovaries removed, or others who have very low estrogen, are at increased risk of bone loss and fracture. Cannabinoids regulate this system, stimulating bone formation via CB1 activation and slowing the rate of break-down via CB2 activation, and so marijuana may compensate for factors which could otherwise drive osteoporosis. (Scutt, 2007; Bab, 2009) As an anti-inflammatory and muscle relaxant, marijuana can also improve flexibility and provide relief for everything from soreness after exercise to certain types of arthritis. Indeed, endocannabinoid activation has been found to occur naturally following exertion, and is believed to allow for longer periods of exertion in what’s known as the “runner’s high.” (Sparling et al, 2003) I have observed marijuana use in the wild stimulating the user to begin exercising or facilitating continuation of exercise despite fatigue. I have also seen the opposite: half hearted attempts at exercise followed immediately by cessation. On the one hand, it may be that marijuana makes it easier to continue doing what one was already doing, such as either running or lying on the couch. On the other hand, it sometimes triggers a reversal, from low energy to high energy or vice versa. Like the endogenous runner’s high, using marijuana when fatigued may produce a “second wind” and allow the user to continue. The cardio-pulmonary dilation, discussed above, is also relevant, as it may improve oxygen availability during exercise.

In summary, marijuana rebalances bone growth, muscle fatigue and inflammation in ways which may correct for or prevent certain forms of imbalance, such as age related bone loss and pain after exercise



Marijuana and the Immune System

THC has been experimentally shown to inhibit certain immune functions — in particular, lymphocyte activity — and to augment others, (Cabral, 2001) and marijuana also contains a variety of antimicrobial agents. (Nissen, et al, 2010) These immunological effects can protect against numerous auto-immune disorders, increase healing and down-tune immune responses. It is likely the case that marijuana can protect against certain kinds of infections under certain conditions, and that it can increase vulnerability to other infections under other conditions. Cannabis oil, especially applied topically, may be an effective treatment for acne, psoriasis (Wilkinson 2007), contact dermatitis (Karsak et al, 2007) as well as a variety of other inflammatory or allergic responses, and against certain infections because of its direct anti-microbial effects.

In summary, marijuana rebalances inflammation and other immune responses and may correct for or prevent certain forms of imbalance, such as autoimmune disorders.


Marijuana has very complicated effects throughout the body. Many of these effects are often highly valued and sought for a wide variety of reasons. Some of these effects can in some situations can be undesirable, and THC by itself has been implicated in a variety of potential harms, including anxiety, psychosis-like mental effects, heart attack and immune suppression. It is necessary therefore to emphasise the importance of using cannabis flowers instead of isolated chemicals such as pure THC, because of the ways in which the other chemicals in the flowers compensate for, counteract, or amplify the effects of THC. (Russo, 2011) Whether marijuana will boost or inhibit each bodily system depends on the state of the body at the time of use, the chemical makeup of the marijuana being used, and the dosing strategy. Smoking one small hit one evening per week may well have the opposite effect of consuming cannabis oil throughout the day every day; the former may be primarily stimulating whereas the latter may lead to a generalised relaxation and slowing of metabolism. As either/both may be desired by each user, preferences in plant variety and dosage strategy vary accordingly. Some people react badly to the plant, whether for mental, cognitive, hormonal or ideological reasons, and some are allergic to it; for many others, it can be profoundly helpful, providing a way by which to take some conscious control over the regulation of homeostasis and to seek a balance which will work for us.

The above is my best understanding of what marijuana does. Although I have here leaned mostly upon scientific journal articles, which I have tried both to understand and to interpret, I am not in fact an advanced specialist in every relevant discipline — nor, I suspect, is anyone else; my academic background is as an ethnographer, and so I consider my primary responsibility to be towards the humans using the plant, for whatever reasons, and with whatever consequences, and I engage with the scientific literature in order to better understand and interpret the observations I have made in the wild, the many curious things I have been told in interviews both formal and informal. I am absolutely certain that there is very important information about the effects of this plant which I do not understand or which I have not yet seen. If you know of anything useful, or suspect that something I have said is inaccurate, incomplete or in other ways merits revision, I would be happy to hear your suggestions. May my best endeavours to faithfully convey my observations be useful to you.

Happy 420!
Can you smell the flowers?

None. Some years ago I took a vow never to sell any drugs about which I expected to write, so as to avoid conflict of interest. I am, however, almost completely out of money, and would be very appreciative of donations and/or job offers so that I can continue to live, buy groceries, learn and write. (no paypal; can accept email money transfers to michaelvipperman@gmail.com, or food offerings in Toronto area only)

Donations received as of 8:45 PM, May 2, 2014: $10.

Proof reading provided by James Birch, Lav Dimitrije and A.C. Patterson.

I own the rights to none of the images.


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  1. fantastic submit, very informative. I’m wondering why the other specialists of this sector do
    not realize this. You should continue your writing. I’m sure, you’ve a huge readers’ base already!

  2. This is absolutely AWESOME!! Thank you for providing such a fabulous resource about the HARMONIOUS effects of Cannabis! #CBD #LoLovesit

    • Thanks! Glad you liked it. I’ve got some even better material now but it’s not public yet… stay tuned!

        • I Ess
        • April 25th, 2016

        A little late here…but did you make the aforementioned material public? And if so, where can I find it.. Thanks!

    • kelly
    • February 3rd, 2015

    thanks so much for taking the time to compile and write this. very informative and user friendly 🙂

  3. Medicinal marijuana use dates back to the earliest eras of medicine and pharmacology, when humans first began to deliberately use plants for their effects on the body rather than simply as a source of nutrition.


    • jose
    • July 28th, 2015

    You said alot… but to the average reader… makes no sense… not even in the conclusion. Sum this shit up in one punch line. Give a ultimate pro and heaviest con…

    • James McGrath
    • October 5th, 2015

    This is the absolute best (most accurate and extensive) explanation of the full and varied effects of marijuana on the human body and mind I’ve come across.

    • James McGrath
    • October 5th, 2015

    …I myself have called cannabis oil for the biological machine.

  4. Arguably the best piece of literature I have ever read on Marijuana and Cannabis. Keep them coming, and if this doesn’t automatically add my email address to your blog releases, than please add it.

  5. ¡Muchísimas gracias! La información en este ensayo ayuda a todos a ver todo del argumento de cannabis, sus beneficios y sus riesgos. Ojalá que todos dar en cuenta la evidencia de las drogas. Los seres humanos han cambiado su estado presente de mente desde siempre.. Es una necesidad de cada persona.

  6. Very complete article ! Many thanks for sharing it with us !

  7. I have said for years “cannabis = homeostasis” I plan to read the full article later, but had to chime in after reading the first line. 🙂

    • K
    • February 8th, 2016

    please research on the facts of marijuana use. I am a collage student taking a phycology class and where cannabis actually increases your brain function and its overall growth tobacco shrinks your brain and causes it to loose function. all smoking can cause cancer UNLESS you ingest cannabis products for the effects. There is absolutely no way you can overdose unless you’ve bought some that had been tampered with and laced with something else, this is why we need it sold in stores instead of on the street to keep innocent people safe. And I’m sorry I laughed at the HIV and leprosy part… you guys are just finding some excuse to hate weed. There are no dirty needles with heroin and if you smoke by yourself you wont have contract with anyone else making it so you cant be able to contract even a simple cold PIRIOD. get your facts strait before you attempt to defile sometime harmless which is less hazardous then tobacco and alcohol.

    • K
    • February 8th, 2016

    also malaria is a disease you contract from MOSQUITOS most common in AFRICA. influenza is a flu that went around for a short time. and TB? if you’ve ever reaserched TB youll be well aware this is not how you get it. its a genetic disease not something you get from smoking pot. I would be typing all day and night about the benefits if I had the time to get through to people who refuse to see the facts and join the bandwagon because of lies.

    • K
    • February 8th, 2016

    I am sorry I just read some of the blog… I saw the picture of the pros and cons and I just kind went off on the subject.

    • lol, you’re not the first one. I thought it was obvious enough that it was parody for people to be able to tell, but apparently not.

      • Got the parody there Michael- seems obvious how addicted we are to the visual. I wonder how many got past that photo and actually read? I must say- this is possibly the best article I have read on the effects of cannabis on our body- and I’ve read a few. (o; Science made comprehensible but a distance from popular lore and hearsay. Glad to have made your acquaintance.

      • Michael- I am just setting up my wn blog- as you can see, it is not up and running yet. I would be honored if the first article I were to share there would be yours. Permission granted? Problem is- I am a newbie and have no idea as to how to share something from one wordpress blog to another…is there a shortcut?


    • daniel
    • March 4th, 2016

    thank you bro weed is good!!!!

  8. I Ess :

    A little late here…but did you make the aforementioned material public? And if so, where can I find it.. Thanks!

    I’m currently pretty bogged down to be honest. I wrote a third draft last year citing 567 sources, and then reviewed another couple hundred, wanting to write a fourth draft before making it public. But I’ve been having health problems and haven’t been feeling well enough to finish, and I still have a huge stack of more papers I’d like to review. I can provide the third draft for now. Hopefully the fourth will exist before too much longer. I wanted to have it ready for 4/20 but, alas…

      • I Ess
      • April 26th, 2016

      Thanks for the timely reply! Are you still accepting donations? I’d be very happy to offer services/food, as I’ve found this comprehensive piece extremely helpful. I would also be interested in speaking with you and am located in TO. If any of these sound good to you, pls let me know how I can contribute and if you are open (and feeling well enough) to meet for discussion.

      • Yes! I’d gladly accept donations, and am happy to meet for discussion. I live on the Danforth. If you’ll provide your email I can send you the third draft of my paper, if you’d like

    • Michael- how is that third/fourth draft coming? Would love to have a copy….

    • Misty
    • June 3rd, 2016

    All I can say is wow. I knew some of this from my own experience. I have had to abstain for a period as to prove that I’m not a bad mom because I’ve used. I find all of your observations and general research to be spot on.

    In my own story, I’ve been subject to abuse from early childhood through the end of my first marriage. Physical, sexual, mental as a child with my step dad being the abuser, up to mental and emotional within my first marriage.
    I became a user towards the last year or two of my first marriage, with my now ex husband asking as to why I could deal with him better when I was high. He smoked with me at times, but mostly I kept it to myself. He could only tell when I had smoked because I seemed more relaxed around him and the children.
    He leaves and tells the kids he might be back if I don’t get a boyfriend. The control in that relationship was more than I could bear.
    I get remarried about 10 months after my divorce is final. I got pregnant just after or before my divorce was finalized. She was born 2 months before I got remarried. I used cannabis through my whole pregnancy, despite the propaganda I believed. My new husband had been using cannabis for pain in his shoulder, in which he was born without his small and large pectoral muscles on his right side.
    The nausea medicine I was prescribed didn’t help me eat while pregnant. I was HUNGRY. I used enough to make me hungry at any given point throughout my pregnancy. I was scared shitless to think she might be taken from me because of my use. My water broke, on the way to the hospital my husband and I smoked. I didn’t feel any contractions until the doctor finally gave me pitosin to hurry things along since my water had already broke. In the pushing part, I was requested to stop, as the cord was wrapped around her neck. I stopped as well as I could. They fixed it and she was born.
    She’s now 3 years old. She’s the smartest little 3 year old I’ve ever been around. Uses her father logic against me most days. Learns everything at an incredible rate. She’s short, but that runs in both of our families. She learns so well, that after she started talking, I started teaching her Spanish, sign language via Signing Time on Netflix, some Chinese and German. She identifies those of the Spanish speaking culture and practices when she can. She can be reasoned with on any level. She’s empathetic in all regards. Simply, she’s amazing!
    In my life, I’ve experienced a lot of sickness, from Scarlet Fever to busted ear drums to bronchitis and pneumonia. In the past four years of having access to cannabis, I’ve experienced my best health ever. Since being ordered to stop using by a court because of my ex husband, I’ve been sick again. It prompted my extensive research into cannabis and our endocannabanoid system. I’m not a scientist by any means, but when one has an interest in being healthy, one does what one has to do. I’ve advocated for the legalization of Cannabis with emails to various Senators and Legislators. I tell my story. I follow up with my research.
    I’ve only begun to search in the Holy Bible for answers.
    I close the Bible, ask a question to God, close my eyes, open the Bible, point to a place on that page, and read.
    The very first one I read was of King Solomon and the harlot. She fragranced her bed with Myrrh, cinnamon, and aloe. That prompted me to Google Myrrh, because it was also gifted to Jesus Christ at birth. I cross reference everything. Myrrh has the same properties as Cannabis. Myrrh was used in the Holy anointing oil used by Jesus to heal humans. I don’t just believe in God and Jesus Christ, but in Science and God. And there are tons of correlations in the two.
    I hope this helps in your writing and research. Again, it’s just my story, one in a billion. I hope this also prompts others to look into their history and at their own lives for answers.

    • Marni Moretti
    • August 26th, 2016

    I could not agree more. It has helped me in so many ways… unfortunately it is illegal in PA.

  9. Thank you so much for your wonderfully reserached and clear series of articles on cannabis benefits. I have reblogged them all.
    My young brother has just been diagnosed with Motor Neurone Disease and I am researching treatment options for him. Just so shocking that he isn’t given the option of cannabis as treatment. He’s under the care of King’s College neurology which makes me nervous in the light of your article on their Psychosis department.
    Keep up the good work, MND sufferers desperately need advocates for cannabis medicine.
    Heartfelt thanks again.

    Reblogged this on https://turnthingsupsidedown.wordpress.com/

    • King’s College is a prestigious and well respected institution. I’d hope they’d treat him well and I hope for the best possible outcome. Their psychosis studies department has some shocking problems with it but hopefully other departments are better. Also hopefully we get more research into cannabis or cannabinoids for many diverse conditions, particularly neurological, degenerative and inflammatory conditions, for which it seems quite promising

    • Carol
    • September 25th, 2016

    Have you any comment on the problem of essential tremors. The drug I was put on seems to do nothing and stops me sleeping. I am mildly diabetic , and over weight, low thyroid function but really quite healthy. Sounds silly does it not. But the hand tremors are a real problem. Thanks Carol

    • I don’t know a lot about tremors, sorry. Different people react differently to different drugs, including cannabis. There are definitely many people for whom cannabis quiets their tremors, and there are also a few people for whom cannabis seems to cause tremors. Your mileage may vary. More research needed.

    • Kevin Garcia
    • October 5th, 2016

    Hey there, would you be able to shed some light on how Marijuana ‘Dampens’ Your Brain’s Response To Rewards?

    • Well on a basic level, cannabinoids reduce the excitability of many different cell types, so they dampen all kinds of things. Some studies have found slightly lower levels of dopamine in the brains of regular smokers, so that could have to do with that dampening, though the effect isn’t very large. Most studies looking at motivation and response to reward have only found them to be significantly reduced in cannabis users who already suffered from depression, so a lot of it is confounded… depressed people are constantly stressing themselves out, so that it relieves stress both protects their brains and also reduces their need to do much. Stress in general could be a way to think about it, that being stressed out can motivate us, so that it provides stress relief can plausibly dampen motivation right there. As an oversimplification, cannabis has the effect on neural networks of pushing them in the direction of more, weaker connections, instead of fewer, stronger connections. Inflammation does the opposite, sensitising synapses and burning out neurons if they’re overstimulated so the network structure is weakened but individual connections are comparatively strong. Dampening this, again, can protect the brain against damage, but could plausibly dampen a whole lot of things. But before you read too much into that or think it’s a giant public health problem, or a social/moral problem, look at the effect sizes. It’s not as big a deal as some make it sound.

    • November 3rd, 2016


    • Big a
    • November 4th, 2016

    This guy is stupid the governments them selfs are saying that cannabis prevents cancer and he’s putting stupid pictures saying there’s no benefits si if you get cancer do use weed when your ‘prescription’ drugs don’t work drugs that you can over dose on unlike weed it’s funny how people can publish si much about weed when the know nothing about it.

    • विक्रम
    • November 4th, 2016

    Dear Michael

    Money will run behind you, I am still reading your article. Started half hour ago, now its close to 2am.

    Brilliant research.I am self educated in Sanskrit and ancient literature and found a drink which is the holy grail or antiageing and immune booster. My mother was suffering from Dengu, there is no research proven allopathic medicine to say with medical research evidence that xyz allopathic medicine can cure Dengu.

    What I gave her is a immune booster and have everything in a measured quantity including Cannabis oil. She got well and.better than before in just 3 days.


    • Lulu
    • January 7th, 2017

    All this website is saying about Marijuana is not correct. This website belongs to drug dealers that take the Marijuana user’s money and fill their pockets . Don’t fall for it. Marijuana is dangeres and makes people numb and stupid. It is not easy to get out of it. But please try hard and stay away from this stuff.

    • Untrue. I do not take money from the sale of marijuana. In fact I’ve fastidiously avoided any conflict of interest.

  10. I would like to see the latest draft if you are able to send it please.

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  12. I used to be suggested this web site through my cousin. I am not
    certain whether or not this publish is written by means of him
    as no one else recognize such distinctive about my problem.
    You are wonderful! Thank you!

    • Jd
    • May 24th, 2017

    Looking forward to reading this, but pretty frustrating you call it marijuana!! Come on now… It’s Cannabis.

    • Cannabis is a less specific term which refers, in Latin, to the whole plant, and is synonymous with the Germanic word hemp, which is itself derived from the word cannabis. Marijuana on the other hand refers specifically to the cured female flowers, and probably derives from the Chinese “ma ren hua,” literally “hemp seed flower,” via Mexican Spanish. “Hemp” or “cannabis” can refer to whole plants, or fabrics, or any number of other things. “Marijuana” always refers to the product we like to smoke, and never to anything else. It’s a perfectly good word. Americans have a taboo against it only because of anti-Mexican racism; up here in Canada, where it’s not in our geopolitical interests to hate Mexicans, we embrace the word.

    • corynski
    • June 15th, 2017

    Thank you very much Michael for such a comprehensive review. Over 50 years ago in Mexico city a friend and I first encountered marijuana, and now finally someone can tell me the truth about it. Truly it is one of the most interesting plants in existence….. and a government has banned it? A plant that so obviously is medicine and they can’t admit it? How tragic our leaders can’t relate to reality and act in the interest of its citizens.

    • Dr. Goldsiten
    • July 25th, 2017

    Your an Idiot, Theres so many false statements here. I cant believe I read this whole this but ay its 2017 now. Read The new studies .

    • This article is indeed somewhat out of date. Which statements in particular do you feel require updating, due to which recent studies?

  13. Everyone loves what you guys tend to be up too.
    This sort of clever work and coverage! Keep up the awesome works guys I’ve you guys to my
    own blogroll.

  14. I began MedCanna use in 2010! … since that time, I have had moles fall from my body, Oral herpes eliminated, fatty liver gone, HepC in dormancy(proven), sever Arthritis controlled – no other pain “remedies” in use, heart murmur disappeared, low BP, severe COPD – -> I have been free of ALL Pharmaceuticals since July1st, 2012! … but is it really Cannabis doing all this? lol (-*-)

      • charles coryn
      • February 19th, 2018

      David, I certainly think it is the cannabis. Personally I have just turned 80 and have been doing OK it seems, considering my association with cannabis of over 55 years. I just had a chest exam and the doctor says ‘OK’….. and I’m still working and living a productive life. And have given up about half of my prescription meds……May I suggest to you and everyone interested to keep up with the research thru the IACM, The International Association of Cannabinoid Medicines, Amsterdam, Holland:


  15. Sometimes by losing a battle you find a new way to win the war.

    • Angela S.
    • December 3rd, 2017

    I can vouch for my own experience with Cannabis only, I’ve been vaping Cannabis for a year straight now and I’m astounded by the health improvements 😍😁💚 I have RA, GERD, peptic ulcers, fibromyalgia, ankylosing spondylitis, degenerative disc disease(another form of arthritis), asthma, Graves’ disease (now hypothyroidism, on hrt), anxiety, insomnia, and also have been on high doses of opioids for over a decade (😰, with the help of Cannabis, I’ve reduced my dosage of opioids and am mainly taking them as a taper down dose for withdrawal symptoms more than they help with pain anymore…) I’m a bit of a mess, all of these is being better behaved now, all forms of it improving little by little, they’re not gone to be clear, I’ve been on one form of “bio”(Enbrel, Humira, Orencia, etc. biological medication to suppress immune system) since 2003. Still am, Xeljanz now, it helps, but since starting what I call micro dosing different specific strains,(I pay special attention to the terpene profiles for their specific effects as well 😁😍, that’s what I found is key for my medication plan with Cannabis), I’ve had less flair ups with all of those health issues and I’ve also lost 40lbs (all intentional, only major change to diet is cut down on breads&processed sugars,not a huge change, nor a huge change in exercise habits,I’ve just recently increased my walking distance from one mile a day to almost three miles a day, in just the last three months,but I lost most of the weight before September of this year), I can’t attribute the weight loss to any changes in thyroid hormone replacement dosage can account for, because I’ve been battling my weight since starting the opioids and it seems a lot of health issues started after opioids had been in my system for three years straight), Cannabis is the only factor that is different this year for attempted weight loss, healthy weight loss at that. Yes, it’s helped with my energy, I call it better than coffee 😎 as with every “medication” “Dosage is Key”. I’ve also recently and successfully used these specific strains (Blue dream for sinus symptoms and asthma symptoms, Acapulco gold for headaches, pain, Jack Frost for relaxing the muscles and at least for me, helped me to relax enough to sleep, and Harlequin high cbd for relaxing, headache, anxiety, while keeping a very clear head (I’ve been paying attention to these factors as well as thc&cbd content, I’ve noticed that most of the strains that help me have measurable and posted amounts of either or both “THCA, CBDA” and I know they’re important too, I’d love to see classes available for these desperately needed kinds of research, wishful thinking I know, but I have hope), and so far completely alleviate and keep at bay a congested, very painful sinuses(that’s how it started), dripping nose, aches and pains from cold/flu, insomnia from the painful sinuses, while keeping down to almost nothing my need for otc antihistamines and decongestants. I hope this helps, thank you for your time and help discovering more about this, shall I dare say it, yes, miracle plant, and happy “it’s 4:20 somewhere 💚💚💚”

  16. Hey. I liked your post. You should check out a post I made on Marijuana as well :). Mine is about the perceptual and crazy effects that are possible. It also finds a possible physiological explanation for perceptual changes that might reveal something fundamental about the mechanics our perception.


  17. The Bible shows the way to go to heaven, not the way the heavens go.

      • charles coryn
      • February 18th, 2018

      Thad Uhlman……..Excuse my intrusion but I’m looking for an email address for Michael. Perhaps you could forward this latest newsletter item from the IACM, the International Association for Cannabis Medicines……… Pretty stunning news at that…….. Thanx, charley

      Science/Human: The medical use of cannabis improves cognitive performance

      The medical use of cannabis improves performance of tasks testing cognition. This is the result of research by scientists of the McLean Hospital in Belmont, USA. Participants were tested before starting the intake of cannabis and 3 months later. Patients completed the Multi-Source Interference Test (MSIT) while undergoing functional magnetic resonance imaging (fMRI). The MSIT was designed to study normal human cognition and psychiatric pathophysiology.

      Following 3 months of treatment, cannabis patients demonstrated improved task performance accompanied by changes in brain activation patterns within certain brain regions (cingulate cortex and frontal regions). Authors wrote that after cannabis treatment, “brain activation patterns appeared more similar to those exhibited by healthy controls from previous studies than at pre-treatment, suggestive of a potential normalization of brain function relative to baseline.” They concluded that their findings suggest that the medical use of cannabis “may result in different effects relative to recreational marijuana (MJ) use, as recreational consumers have been shown to exhibit decrements in task performance accompanied by altered brain activation.” Patients also reported improvements in clinical state and health-related measures.

      Gruber SA, Sagar KA, Dahlgren MK, Gonenc A, Smith RT, Lambros AM, Cabrera KB, Lukas SE. The Grass Might Be Greener: Medical Marijuana Patients Exhibit Altered Brain Activity and Improved Executive Function after 3 Months of Treatment. Front Pharmacol. 2018;8:983.

      • Thanks. I check this old blog occasionally. I’ll add that paper to my review pile. I already have a half dozen or so citations to that team. This one looks pretty good.

        • charles coryn
        • February 21st, 2018

        Michael…. Excuse my error regarding the name…. it’s International Association for Cannabinoid Medicines. I’ve followed this publication for many years, please do check it out. My introduction to cannabis medicine was in Mexico in 1959 and it has been useful especially for RLS Syndrome throughout the years. My chest Xray last week was good my doctor said, and at 80 I feel like 60. Used for thousands of years as medicine, here in Tennessee they confiscate and burn it. Curious behavior indeed……. My thanks again for an excellent discussion.

    • Sean Woodruff
    • February 18th, 2018

    I disagree

      • charles coryn
      • February 19th, 2018

      Yes, Sean, you disagree with what? Would you care to discuss it?

      Here is the concluding remark of the Laguardia Committee Report on Marijuana:

      “As measured by the succession of arrests and convictions in the Court of General Sessions (the only method of estimation) it can be said the drugs generally do not initiate criminal careers. Similarly, in the Court of Special Sessions, only 8 per cent of the offenders had previous charges of using drugs and 3..7 per cent had previous charges of using drugs and 3.7 per cent had previous charges of drugs and other petty crimes. In the vast majority of cases in this group of 135, then, the earlier use of marihuana apparently did not predispose to crime, even that of using other drugs. Whether the first offenders charged with the use of marijuana go on to major crime is a matter of speculation. The expectancy of major crimes following the use of cannabis in New York County is small, according to these experiences.”

    • Evelyn Ray
    • March 16th, 2018

    In April of last year, i started on natural parkinsons disease herbal treatments from RICH HERBS FOUNDATION, i am happy to report this PD herbal treatment worked very effectively. My parkinson is totally under control, i had a total decline in symptoms, the tremors, shaking, stiffness, congnition and speech problems stopped. Visit rich herbs foundation official web page ww w.richherbsfoundation .com. My family are amazed at the change and rapid improvement.

    • charles coryn
    • February 13th, 2020

    Greetings Michael…… Are you still writing and publishing? I’ve just finished my 60th year of cannabis use and am in good health. Recovering from a hip replacement now, and am still amazed at how cannabis is and isn’t accepted by the world…….

    • Bwambale
    • July 15th, 2020

    Cannabis is not very addictive compared to illicit drugs so where did the notion that it is a gateway drug come from?

    • cbd oil for pain
    • September 28th, 2020

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    • 100 pure cannabis oil
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    I will be on the lookout for more of your work.

  18. Nice post. Well what can I say is that these is an interesting and very informative topic on Medical Marijuana

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